Tag Archives: Oncology

Researchers Discover New Mechanism Linking Diet and Cancer Risk

MGO, a glucose metabolite, can temporarily destroy the BRCA2 protein, reducing its levels in cells and inhibiting its tumor-preventing ability.

Via friends at epochtimes. You may have heard that sugar feeds cancer cells, and evidence supports that. However, the missing link in this narrative has been a thorough understanding of just “how” sugar feeds cancer—until now. A recent study published in Cell in April uncovers a new mechanism linking uncontrolled blood sugar and poor diet with cancer risk.

The research, performed at the National University of Singapore’s Cancer Science Institute of Singapore, and led by professor Ashok Venkitaraman and Li Ren Kong, a senior research fellow at the University of Singapore, found a chemical released when the body breaks down sugar also suppresses a gene expression that prevents the formation of tumors.

This discovery provides valuable insights into how one’s dietary habits can impact their risk of developing cancer and forges a clear path to understanding how to reverse that risk with food choices.

Methylglyoxal–A Temporary Off Switch

It was previously believed that cancer-preventing genes must be permanently deactivated before malignant tumors can form. However, this recent discovery suggests that a chemical, methylglyoxal (MGO), released whenever the body breaks down glucose, can temporarily switch off cancer-protecting mechanisms.

Mr. Kong, first author of the study, stated in a recent email: “It has been shown that diabetic and obese individuals have a higher risk of cancer, posing as a significant societal risk. Yet, the exact cause remains debatable.

“Our study now unearthed a clue that may explain the connection between cancer risk and diet, as well as common diseases like diabetes, which arise from poor diets.

“We found that an endogenously synthesized metabolite can cause faults in our DNA that are early warning signs of cancer development, by inhibiting a cancer-preventing gene (known as the BRCA2).”

BRCA2 is a gene that repairs DNA and helps make a protein that suppresses tumor growth and cancer cell proliferation. A BRCA2 gene mutation is associated primarily with a higher risk of developing breast and ovarian cancers, as well as other cancers. Those with a faulty copy of the BRCA2 gene are particularly susceptible to DNA damage from MGO.

However, the study showed that those without a predisposition to cancer also face an increased risk of developing the disease from elevated MGO levels. The study found that chronically elevated levels of blood sugar can result in a compounded increase in cancer risk.

“This study showcases the impact of methylglyoxal in inhibiting the function of tumour suppressor, such as BRCA2, suggesting that repeated episodes of poor diet or uncontrolled diabetes can ‘add up’ over time to increase cancer risk,” Mr. Kong wrote.

The Methylglyoxal and Cancer Relationship

MGO is a metabolite of glucose—a byproduct made when our cells break down sugar, mainly glucose and fructose, to create energy. MGO is capable of temporarily destroying the BRCA2 protein, leading to lower levels of the protein in the cells and thus inhibiting its ability to prevent tumor formation. The more sugar your body needs to break down, the higher the levels of this chemical, and the higher your risk of developing malignant tumors.

“Accumulation of methylglyoxal is found in cancer cells undergoing active metabolism,“ Mr. Kong said. ”People whose diet is poor may also experience higher than normal levels of methylglyoxal. The connection we unearthed may help to explain why diabetes, obesity, or poor diet can heighten cancer risk.”

MGO is challenging to measure on its own. Early detection of elevated levels is possible with a routine HbA1C blood test that measures your average blood sugar levels over the past two to three months and is typically used to diagnose diabetes. This new research may provide a mechanism for detecting early warning signs of developing cancer.

“In patients with prediabetes/diabetes, high methylglyoxal levels can usually be controlled with diet, exercise and/or medicines. We are aiming to propose the same for families with high risk of cancers, such as those with BRCA2 mutation,” Mr. Kong said.

More research is needed, but the study’s findings may open the door to new methods of mitigating cancer risk.

“It is important to take note that our work was carried out in cellular models, not in patients, so it would be premature to give specific advice to reduce risk on this basis. However, the new knowledge from our study could influence the directions of future research in this area, and eventually have implications for cancer prevention,” he said.

“For instance, poor diets rich in sugar or refined carbohydrates are known to cause blood glucose levels to spike. We are now looking at larger cancer cohorts to connect these dots.”

The Diet and Cancer Connection

Dr. Graham Simpson, medical director of Opt Health, stated in an email: “It’s genes loading the gun, but your lifestyle that pulls the trigger. Every bite of food you take is really information. It’s either going to turn on your longevity genes or it’s going to turn on your killer genes. So cancer is very much in large part self-induced by the individual diet.”

A 2018 study published by Cambridge University Press found an association between higher intakes of sugar-sweetened soft drinks and an increased risk of obesity-related cancers. Research published in the American Journal of Clinical Nutrition in 2020 concluded that sugars may be a risk factor for cancer, breast cancer in particular. Cancer cells are ravenous for sugar, consuming it at a rate 200 times that of normal cells.

Healthy Dietary Choices for Reducing Cancer Risk

A consensus on the best dietary approach for reducing cancer risk has yet to be determined, and further research is needed. However, the new findings of the Cell study on MGO support reducing sugar intake as a means to mitigate cancer risk. A study published in January in Diabetes & Metabolism shows that a Mediterranean diet style of eating may help reduce MGO levels.

In 2023, a study published in Cell determined that a ketogenic diet may be an effective nutritional intervention for cancer patients as it helped slow the growth of cancer cells in mice—while a review published in JAMA Oncology in 2022 found that the current evidence available supports a plant-enriched diet for reducing cancer risk.

Dr. Simpson stressed the importance of real food and healthy macronutrients with a low-carb intake for the health of our cells. “The mitochondria is the most important signaling molecule and energy-producing organelle that we have in our body. [Eat] lots of vegetables, healthy proteins, and healthy fats, fish, eggs, yogurt,” he said.

“Lots of green, above-ground vegetables, some fruits, everything that is naturally grown and is not processed.” For the Silo, Jennifer Sweenie.

WHY Meditation Is Science Approved Medicine

Ohm! There have been countless anecdotal claims about the benefits of practicing meditation since the Eastern tradition has become more popular in the West.

 Now, there’s plenty of Western-based scientific evidence to support them, says Dr. Matt Mumber, a radiation oncologist and co-director of a non-profit integrative oncology program. 

“Meditation is to the brain what physical activity is to the body. We’ve found meditation to be an important facet of health care, both for prevention and maintenance as well as in the treatment of disease, including cancer,” says Dr. Mumber, co-author with colleague and Yoga instructor Heather Reed of “Sustainable Wellness: An Integrative Approach to Transform Your Mind, Body, and Spirit,” (www.sustainablewellnessonline.com).

Mumber and Reed, who are co-facilitators of non-profit residential retreats for cancer patients, say one can experience sustainable wellness by developing a life practice grounded in the cultivation of awareness. This awareness is paying attention without attachment. The ability to be aware can be increased by a meditation tool called mindfulness.

“Life is a constant series of adjustments, matching your inner being with your outer doing,” Reed says. “One way to heighten your awareness is through practicing meditation.”

Mumber and Reed say there’s plenty of new evidence that the resulting sense of balance and peace is not just a psychological effect:

• Mindfulness meditation leads to increases in regional brain gray matter density: Recently published in Psychiatry Research: Neuroimaging, shows that measurable  changes in gray-matter density in parts of the brain associated with memory, sense of self, empathy, and stress occurred with study participants who meditated for 30 minutes a day for eight weeks.

• Meditation practitioners have longer attention spans: Published by the journal PloS Biology, a study analyzed people with three months of rigorous training and found that they gained a drastically improved attention span – not only longer, but less susceptible to internal or external distraction. They also showed improved memory and enhanced performance in several tasks, from driving a car to playing piano.

• Reduces stress and blood pressure: Presented to the American Heart Association by researchers at the at the Medical College of Wisconsin in Milwaukee and the Institute for Natural Medicine and Prevention, a study including 200 high-risk patients for heart attack found that meditation reduced their chances for heart attack by 50 percent.

Oncologist Matt Mumber co-author of Sustainable Wellness
Oncologist Matt Mumber co-author of Sustainable Wellness

“Studies involving people seeking to reduce stress and other problems in their lives via meditation will continue, as well as for those who want to enhance performance of various duties,” Mumber says.

“For those skeptical of the medical benefits of this Eastern practice, there’s now plenty of Western proof.” Matt Mumber, MD

Matt Mumber, MD, is a practicing board-certified radiation oncologist with the Harbin Clinic in Rome, Ga. He completed his radiation oncology residency at Wake Forest University Bowman Gray School of Medicine and graduated from the Associate Fellowship Program in Integrative Medicine at the University of Arizona. Dr. Mumber is past president of the Georgia Society of Clinical Oncology. He founded Cancer Navigators Inc, a non-profit organization offering cancer patients access to nurse navigation, social services and educational programs to support and augment the clinical care they receive. Dr. Mumber received the Hamilton Jordan Founders Award for involvement in statewide oncology activities and in 2008 he was named a Health Care Hero by Georgia Trend magazine. He serves on the editorial board for the journals Current Oncology and Journal of Oncology Practice and is on the board for the Society of Integrative Oncology. 

 

Yoga instructor Heather Reed of “Sustainable Wellness: An Integrative Approach to Transform Your Mind, Body, and Spirit
Yoga instructor Heather Reed of “Sustainable Wellness: An Integrative Approach to Transform Your Mind, Body, and Spirit

Heather Reed has been teaching Yoga since 1996. She expresses an integrative, adaptive approach and specializes in using Yoga and meditation techniques for people living with cancer, post-polio syndrome and other chronic illnesses. Heather received an Experienced Teacher Certification from Esther Myers Yoga Teacher Training Program and has had extensive training with senior staff of the Commonweal Cancer Help program and Dr. Dean Ornish’s Program for Reversing Heart Disease. She developed Yoga classes for cancer patients at The Wellness Community, Atlanta. Since 2008, she has been Yoga teacher and co-facilitator for the Residential Retreat Program for Cancer Navigators of Rome, Ga. For the Silo, Ginny Grimsley

Supplemental-  http://well.blogs.nytimes.com/2011/01/28/how-meditation-may-change-the-brain/

Canada Reassessing Glyphosate Roundup Herbicide Link To Cancer

Crop SprayingIt’s been nearly four years since we published the article below and the water surrounding glyphosate use in Canada is still murky. Roundup is currently being used in an official capacity in certain situations by government agencies such as the Ministry of the Environment to fight the invasive species Phragmites. Let’s review the earlier article:

Dear friends across Canada, top scientists warn the most commonly used herbicide in the world probably causes cancer. Monsanto is demanding the World Health Organization retract their ground-breaking report. And experts say the only way to ensure the science is not silenced is if the public demands action, now. The regulatory system is renowned for being secretive and captured by the agro-chemical industry. But we have a unique moment right now — Canada is officially reassessing glyphosate, with similar processes underway in the US, Europe, and Brazil. And the Netherlands, Sri Lanka, and El Salvador are all looking at a ban. [However, it must be noted that as of today’s posting, Canada Health’s Food Safety Inspection statement is that glyphosate formulations ARE safe http://www.hc-sc.gc.ca/fn-an/gmf-agm/seralini-eng.php CP]The threat is clear — this poison is used on our food, our fields, our playgrounds, and our streets. Let’s get it suspended.

Join the urgent call and tell everyone: https://secure.avaaz.org/en/monsanto_dont_silence_science_loc_cn/?bsOTIab&v=57275

Monsanto is up in arms. Glyphosate brings in $6 billion per year. It is the basis of RoundUp, the chemical cornerstone of Monsanto’s Genetically Modified empire. The company says the WHO report ignored studies showing glyphosate is safe. But these scientists are 17 of the world’s top oncology experts, not a bunch of crazies. They comprehensively reviewed independent studies, excluding those done by companies seeking product approval.  Regulators rely mainly on tests done by the companies trying to sell the poisons!

Skeleton Scarecrows

Key results are kept from the public because they contain ‘commercially confidential information’, and 58% of the scientific panels in the EU Food and Safety Agency are linked to the sector. It’s nuts, but that is the system we have. And that’s why it’s going to take all of us to make sure this crucial independent report isn’t ignored. Some countries have already put bans on glyphosate. Now with the EU, the US, Canada, and Brazil all reviewing it, we have an incredible chance to turn the tide worldwide.

Fifty years ago Monsanto’s pesticide DDT was everywhere until the seminal book Silent Spring showed it could cause cancer — a decade later it was banned. If this could cause cancer, let’s not let it be sold for ten more years. Let’s demand emergency precautionary action now.

Join now and spread the word:  https://secure.avaaz.org/en/monsanto_dont_silence_science_loc_cn/?bsOTIab&v=57275

Glysophate360IndustrialAgriculturalPackaging

We’ve done it before — helped win a moratorium on bee-killing neonicotinoids in the EU and stop a Monsanto mega seed factory in Argentina. Now let’s protect our health and make sure we aren’t being used as lab rats. This could be a breakthrough moment in the fight for the safe, sustainable agriculture our world needs. With hope, Bert, Marigona, Antonia, Oliver, Alice, Emily, Danny, Nataliya, Ricken and the whole Avaaz team.

More information: New study points to link between weedkiller glyphosate and cancer (FT)  http://www.ft.com/cms/s/0/8b79a572-cf14-11e4-893d-00144feab7de.html#axzz3XOmCcv9c

Supplemental-

Monsanto seeks retraction for report linking herbicide to cancer (Reuters)  http://in.reuters.com/article/2015/03/24/monsanto-herbicide-idINL2N0WP0UM20150324

Weed Killer, Long Cleared, is Doubted (New York Times)  http://www.nytimes.com/2015/03/28/business/energy-environment/decades-after-monsantos-roundup-gets-an-all-clear-a-cancer-agency-raises-concerns.html

The Real Reason to Worry About GMOs (Mother Jones)  http://www.motherjones.com/tom-philpott/2015/03/bittman-right-its-not-gmos-its-how-theyre-used 

Groups seek EPA glyphosate review after WHO ‘carcinogenic’ link (Agri Pulse) http://www.agri-pulse.com/Groups-seek-EPA-glyphosate-review-after-WHO-carcinogenic-link-03272015.asp  

More sources:  https://avaazmedia.s3.amazonaws.com/Roundupsources.pdf

St. Catharines New Highest Technology Hospital Is Impressive

The Project: The 980,000 sq. ft. acute care community hospital replaces two aging facilities in the Niagara region and accommodates 375 acute care beds, with associated outpatient and support services.

Niagara Health System New Health Care Complex – St. Catharines Site "2oth Century NOT included" CP
New Health Care Complex – St. Catharines Site “2oth Century NOT included”

It provides a comprehensive range of clinical services including:

• a cancer centre serving 1,200 patients close to home, relieving them from the stress of travelling to Hamilton or Toronto for treatments

• a longer-term mental health service that includes 53 beds

• dialysis services

• cardiac catheterization services, which provides diagnostic investigation, reduces hospitalizations for heart disease and provides faster local care for residents of the Niagara region

The goal of this project was to provide Niagara Health System with a modern, state-of-the-art, one million square foot building capable of providing one million square feet of care.

In addition to design and construction management, PCL’s [ PCL comprises a  family of  general contracting companies  and is the largest such organization in Canada and the fifth largest in the U.S. CP ]scope of work also included the procurement and installation of more than 25,000 pieces of medical equipment, as well as medical gas, head walls, nurse call system, information technology, audio visual, and security technology.

Some of the many interesting features that set this building apart include construction of the first radiation suites in the Niagara region, an enclosed ambulance bay to provide protection to incoming patients, an interior design that strategically locates departments to minimize clinical travel time by staff, and an exterior design that implements materials indigenous to the Niagara region.

 

Interior and exterior architectural designs affect patient and staff psychology so why not design accordingly? This ceiling detail of the Walker Cancer Care Treatment Room ceiling reveals the care and consideration that went into the hospitals designs. CP
Interior and exterior architectural designs affect patient and staff psychology so why not design accordingly? This ceiling detail of the Walker Cancer Care Treatment Room ceiling reveals the care and consideration that went into the hospitals designs. CP

 

Architectural

• Main Street feature wall using a combination of indigenous and complementary stones that tell a story of the geological formation of the  Niagara Escarpment.

• Use of structural elements in the form of a tree at the main entry and cafeteria to create the canopy.

• First operating rooms in Canada to use Corian wall finishes.

• Integrated interior finishes and way finding system,using landmarks to help visitors and patients locate themselves in the facility.

• Enhanced use of natural light to infiltrate deeper into the building, with particular attention to patient spaces.

• An acoustical design at the building envelope to mitigate and isolate noise generated by a nearby train corridor.

 

Structural

• Blending structural elements with architectural finish and spectacle.

• Strategy of a structural grid system to maximize open spaces and floor to ceiling height.

• Foundation system and MRI inertia slab to address vibrations created by train traffic and a nearby machine stamping plant.

• Post Disaster design to address potential seismic event, to allow the facility to operate during and after as a relief centre.

• Use of cast-in-place elements to allow equipment flexibility.

Mechanical/Electrical

• Pandemic containment capability to deal with infectious outbreaks and disasters, allowing the facility to isolate building sections and departments.

• Building automation system, fully integrated with building elements and equipment to monitor and ensure optimal building performance.

• Back-up and dual power systems to ensure fundamental building and medical systems remain available and functioning at all times, including integration with the building automation system, to allow targeted load distribution to non fundamental systems to become available as required.

 

The Operating Theater. It's understandable if you think that this is a set from Star Trek-
The Operating Theater. It’s understandable if you think that this is a set from Star Trek-

 

Sustainability

• The project is targeted for LEED® certification. As part of the construction and design strategy, the project team developed several innovations and elements for a significant improvement of the target to LEED® Silver certification – from 26 to 35 points.

• Incorporated an energy efficient lighting strategy using natural lighting as much as possible, as well as the broad use of occupancy sensors and low energy lighting systems.

• Integrated and efficient cooling and heating systems, and an optimized building envelope system that helps to reduce greenhouse gas emissions.

• The overall energy strategy resulted in the Energy Model that realizes an energy savings of 46% relative to the Model Energy Code for Buildings, which is expected to produce savings to the client in excess of $1 million annually.

• Use of native and hardy plant  species and an integrated storm water management program, including irrigation and water features to eliminate city water use for landscape elements.

 

A look at the state-of-the-art radiation treatment facility.
A look at the state-of-the-art radiation treatment facility.

Supplemental- Corian mineral composite wall panelshttp://www.architonic.com/pmpro/corian-panels-mineral-composite-panels-mineral-composite-materials-finishes/3240623/2/2/1

1000 Canadian projects now LEED Certified/What is LEEDhttp://www.dcnonl.com/article/id55463

B+H Architects, designers of St. Catherines new hospital- http://www.bharchitects.com/en/projects/129

PCL Construction, builders of St. Catherines new hospitalhttp://www.pcl.com/Pages/default.aspx